Featured Episodes

Textiles as Tech, Science, Math, Culture, or Civilization

Virginia Postrel and Sonal Chokshi

AI, WebRTC, Crypto, and Full Stack Startups

Elad Gil, Sep Kamvar, and Chris Dixon

Feedback Loops — Company Culture, Change, and DevOps

Nicole Forsgren, Jez Humble, and Sonal Chokshi

Latest Episodes

Why Medical AI Needs a Referee | Protege's Engy Ziedan

Daisy Wolf, Eva Steinman, and Engy Ziedan

Martin Casado on Where the Value Is Going in AI

Martin Casado, Theo Jaffee, and Sophia Dew

Microsoft's Deputy CISO on Securing AI Agents

Joel De La Garza, and Aaron Zollman

How Global Networks Are Reshaping Startup Success

Elena Burger, Angela Strange, and Gabriel Vasquez

How Whatnot Built a Global Marketplace

David George, and Grant LaFontaine

How Do You Defend Against AI That Can Hack?

Joel de la Garza, Nick Warner, and Max Pollard

Stripe’s AI Strategy: Build More, Not Less

David George, and Will Gaybrick

Ben Horowitz and Travis Kalanick on Building Again

Erik Torenberg, Ben Horowitz, and Travis Kalanick

The Two Ways to Sell AI: Lighthouse or Landgrab?

Elena Burger, Joe Schmidt, and Andy McCall

Garry Tan on Taste, Agents and Founder Ambition

Anish Acharya, and Garry Tan

The CISO Playbook for AI Agents | Datadog

Joel de la Garza, and Emilio Escobar

The Self-Improving Company | Kavak's AI Playbook

Gabriel Vasquez, Angela Strange, and Alejandro Maza Ayala

The Reality of AI-Powered Cyberattacks | Truffle Security & Socket

Joel De La Garza, Feross Aboukhadijeh, and Dylan Ayrey

The Engine Powering Open-Source AI

Elena Burger, Matt Bornstein, and Simon Mo

Three Startups Reinventing Critical Infrastructure

Erin Price-Wright, Ryan McEntush, Theo Jaffee, Doug Bernauer, Turner Caldwell, Will O'Brien, and Erik Torenberg

OpenAI's Joshua Achiam: Did We Already Reach AGI?

Theo Jaffee, and Joshua Achiam

Ruby Thelot on Internet Culture, AI, and the Future of Taste

Sophia Dew, Sofia Puccini, and Ruby Thelot

Marc Andreessen and Chris Dixon: What’s at Stake in Crypto Regulation

Robert Hackett, Marc Andreessen, and Chris Dixon

How Enterprise AI Really Gets Deployed

Sarah Wang, Kimberly Tan, Jesse Zhang, and Ashwin Sreenivas

AI for America's Small Businesses | Lassie

Olivia Moore, Alex Rampell, Steijn Pelle, and Frédéric Renken

AI Micro Dramas, Generative Media, and the Future of Creativity

Justine Moore

Fei-Fei Li on Spatial Intelligence and Robotics

Martin Casado, Fei-Fei Li, and Yunzhu Li

Steven Sinofsky: AI Doesn't Need New Rules Yet

Steven Sinofsky, Theo Jaffee, and Sofia Puccini

Ben Horowitz: The Fight Over Open Source AI

Ben Horowitz, Theo Jaffee, and Sofia Puccini

Sriram Krishnan on Open Source AI's Biggest Week Yet

Theo Jaffee, Sofia Puccini, and Sriram Krishnan

Building the Physical AI Stack | Travis Kalanick on TBPN

Travis Kalanick, Jordi Hays, and John Coogan

Travis Kalanick Is Back | Building the Future of Industrial AI

Erik Torenberg, Ben Horowitz, and Travis Kalanick

Why Physical AI Is the Next Frontier | Applied Intuition

Erik Torenberg, Marc Andreessen, Qasar Younis, and Peter Ludwig

Hugging Face's CEO on Open Source AI, Model Routing, and the Future of Competition

Theo Jaffee, Sofia Puccini, and Clément Delangue

Amjad Masad on Going Direct, Building Replit, and the Future of Software

Erik Torenberg, and Amjad Masad

Replay 2025: David Sacks on AI, Crypto, and America's Technology Future

Erik Torenberg, Marc Andreessen, Ben Horowitz, and David Sacks

From the Archive: Can Anyone Catch NVIDIA? | The Future of Chips and Infrastructure

Erik Torenberg, Erin Price-Wright, Guido Appenzeller, and Dylan Patel

Is AI a Bubble? | Gavin Baker on Data Centers, GPUs, and the AI Economy

David George, and Gavin Baker

Before Blockchains, There Was State Machine Replication

Tim Roughgarden, Ittai Abraham, and Barbara Liskov

How Bitcoin Rewired a Classic Computer Science Problem

Tim Roughgarden, and Ittai Abraham

Mark Zuckerberg & Priscilla Chan: How AI Will Help Cure Disease

Ben Horowitz, Erik Torenberg, Vineeta Agarwala, Mark Zuckerberg, and Dr. Priscilla Chan

Adam Neumann: This Is How You Build Iconic Companies

Marc Andreessen, Ben Horowitz, Erik Torenberg, and Adam Neumann

Is Software Losing Its Head?

Seema Amble, Steven Sinofsky, and Elena Burger

Don’t Follow Your Passion | Ben Horowitz’s Advice for New Graduates

Ben Horowitz

a16z Goes Global: Why American Tech Must Lead the World

Ben Horowitz, Anne Neuberger, Raghu Raghuram, and Jen Kha

Outsmarting Uber: Why Bolt Wins in Europe

Markus Villig, and Gabriel Vasquez

Rick Rubin on AI, Creativity, and The Way of Code

Marc Andreessen, Ben Horowitz, Erik Torenberg, Anjney Midha, and Rick Rubin

Building AI for Creators | Luma & Phota Labs

Yoko Li, Matt Tancik, and Zach Xia

Beyond P(doom): Marc Andreessen - Betting on America

Marc Andreessen, and Navin Girishankar

AI Is Crossing the Frontier of Human Knowledge | Kevin Weil

Kevin Weil

Marc Andreessen on AI, Technology, and the Future of Humanity

Marc Andreessen, and Michael Malice

What Happens to Design After AI?

Anish Acharya, John Maeda, and Paul Bakaus

What’s Next for Consumer AI? | Josh Elman Joins a16z

Anish Acharya, and Josh Elman

Jake Paul & Anti Fund: From Creator to Investor

Erik Torenberg, Jake Paul, and Geoff Woo

The New Rules of Media | Marc Andreessen & Ben Horowitz

Marc Andreessen, Ben Horowitz, Erik Torenberg, and Gaby Goldberg

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