Featured Episodes

Textiles as Tech, Science, Math, Culture, or Civilization

Virginia Postrel and Sonal Chokshi

AI, WebRTC, Crypto, and Full Stack Startups

Elad Gil, Sep Kamvar, Chris Dixon, and a16zftr

Feedback Loops — Company Culture, Change, and DevOps

Nicole Forsgren, Jez Humble, and Sonal Chokshi

Latest Episodes

Every Day Is Zero Day | Wiz CTO Ami Luttwak

Sarah Wang, Zane Lackey, and Ami Luttwak

The Next Era of Games: Mods, Agents, and Infinite Worlds

Elena Burger, Anish Acharya, and Jonathan Lai

What the Internet Boom Teaches Us About the AI Buildout | Mike Volpi

Raghu Raghuram, Guido Appenzeller, and Mike Volpi

HubSpot’s Co-Founder on Finding Your Next Startup Idea

Joe Schmidt, and Dharmesh Shah

Scott Kupor on Building a16z and Rebuilding the Federal Workforce

Scott Kupor, and David Senra

The Health Interventions Actually Worth Your Time | Justin Mares

Daisy Wolf, and Justin Mares

Mark Hyman’s Guide to Living Longer and Staying Strong

Daisy Wolf, and Mark Hyman

Inside Salesforce’s $100 Billion M&A Playbook | John Somorjai

Alex Immerman, and John Somorjai

The New CFO: How AI Is Rewriting the Finance Function | Figma CFO Praveer Melwani

Seema Amble, Ivan Makarov, and Praveer Melwani

The New AI Agents That Shop, Plan, and Gossip

Anish Acharya, Josh Elman, and David Pawlan

Andrew Huberman’s Three Rules for Better Health and Focus

Daisy Wolf, and Andrew Huberman

The Robots Already Working in American Factories | Tutor Intelligence

Martin Casado, Raghu Raghuram, and Josh Gruenstein

How Bending Spoons Built a $20 Billion Compounder | Luca Ferrari

Anish Acharya, and Luca Ferrari

Can AI Fix Professional Networking? | Inside Cosign

Sophia Dew, David Booth, and Dhruv Gupta

Why AI Could Turn Small Law Firms Into Billion-Dollar Businesses

Alex Rampell, and Jay Madheswaran

The Startups Rebuilding American Industry | The AD50

Elena Burger, Erin Price-Wright, and Connor Love

Mark Cuban on Why AI Could Turn Solo Founders Into Trillionaires

Erik Torenberg, Julie Yoo, and Mark Cuban

Reinventing School for the AI Era | Joe Liemandt, Gagan Biyani & Erik Torenberg

Erik Torenberg, Gagan Biyani, and Joe Liemandt

OpenAI: When AI Agents Use Computers Faster Than You

Seema Amble, Fabrizio Serafini, Ari Weinstein, and James Sun

The New Startup Playbook | Box CEO Aaron Levie

Aaron Levie

What It Takes to Win as a Founder | Ben Horowitz

Ben Horowitz, and Andrew Chen

Amazon CEO Andy Jassy on the $220 Billion AI Buildout

Erik Torenberg, Ben Horowitz, and Andy Jassy

The Frontier Ideas a16z Wants to Fund | Marc Andreessen, Ben Horowitz & Chris Dixon

Chris Dixon, Ben Horowitz, Marc Andreessen, and Erik Torenberg

The Missing Infrastructure for AI Agents: Documents | Reducto’s Adit Abraham

Jennifer Li, and Adit Abraham

What Happens When Everyone Has a Health Expert in Their Pocket? | OpenAI’s Karan Singhal

Jay Rughani, and Karan Singhal

What Happens When Al Agents Can Spend Your Money?

Alex Rampell, and Jean-Denis Greze

Why Real-World AI Is Harder Than the Benchmark | EliseAI’s Mario Martone

Mario Martone, and Sophia Dew

Why AI Could Finally Fix Healthcare Access | Zocdoc CEO Oliver Kharraz

Julie Yoo, and Oliver Kharraz

AI Can Write the Code. Can It Run the System? | Grepr CEO Jad Naous

Martin Casado, and Jad Naous

When AI Agents Start Spending Your Money | Alex Rampell & Terry Angelos

Alex Rampell, and Terry Angelos

Can Open Models Keep Up With the AI Frontier? | Nathan Lambert

Lisha Li, and Nathan Lambert

Can AI Break Cryptography? What the Experts Actually Think

Liz Harkavy, Eddy Lazzarin, Justin Thaler, and Dan Boneh

The Race to Recursive Self-Improving AI

Martin Casado, Dhaval Adjodah, and Owen He

Nick Bostrom: How Should We Navigate Superintelligence?

Theo Jaffee, Sofia Puccini, and Nick Bostrom

What Makes a Great Entrepreneur? | Ben Horowitz on Vintage x Vintage

Ben Horowitz, and James Norman

Chips, Memory, and Power | Pat Gelsinger

Raghu Raghuram, Guido Appenzeller, and Pat Gelsinger

Building the Cloud for an Agentic World | AWS CEO Matt Garman

Raghu Raghuram, and Matt Garman

How Valon Rebuilt a $13 Trillion Industry From Scratch

Angela Strange, Linda Du, and Andrew Wang

Building Defense for the Agentic Era: Kevin Mandia

David George, and Kevin Mandia

The Top 100 Consumer AI Apps: Who’s Actually Paying?

Elena Burger, Olivia Moore, and Josh Elman

David George & Jack Altman on AI, Autonomy, and the Next $25 Trillion

David George, and Jack Altman

Beyond the God Model | Alex Atallah & Amjad Masad

Erik Torenberg, Amjad Masad, and Alex Atallah

Why AI Agents Can Beat the Incumbents

Elena Burger, Seema Amble, and Vladimir Keil

Rebuilding the Internet for Privacy | Barrett Lyon on DoxxNet

Joel de la Garza, and Barrett Lyon

The $1 Trillion AI Buildout | State of Markets

David George, Sarah Wang, Alex Immerman, and Santiago Rodriguez

The Personal Agent Race Is Here | Anish Acharya & David Pawlan

Anish Acharya, and David Pawlan

AI Can Write Code. Why Isn’t Software Better?

Ben Horowitz, Martin Casado, and Diogo Almeida

Building a Team at AI Speed | Harvey’s Maggie Landers

Katie Kirsch, and Maggie Landers

Aaron Levie, Steven Sinofsky & Martin Casado: How Do You Secure a World of AI Agents?

Erik Torenberg, Martin Casado, Steven Sinofsky, and Aaron Levie

The Reputation Graph of Silicon Valley | Introducing Cosign

Erik Torenberg, Josh Elman, Olivia Moore, and David Booth

More Podcasts From Us

Bio Eats World

From the latest scientific advances to the biggest trends, this show explores all the ways biology is today where the computing revolution was 50 years ago.

16 Minutes on the News

A short news podcast where we cover the top headlines of the week, the a16z podcast way—why these topics are in the news; what’s real and what’s hype.