Featured Episodes

Textiles as Tech, Science, Math, Culture, or Civilization

Virginia Postrel and Sonal Chokshi

AI, WebRTC, Crypto, and Full Stack Startups

Elad Gil, Sep Kamvar, and Chris Dixon

Feedback Loops — Company Culture, Change, and DevOps

Nicole Forsgren, Jez Humble, and Sonal Chokshi

Latest Episodes

World Models, Robotics, and the Future of 3D AI

Theo Jaffee, Sofia Puccini, and Justin Johnson

Why Companies Are Becoming a Series of Loops | Anish Acharya on Lenny’s Podcast

Anish Acharya, and Lenny Rachitsky

What It Takes to Build a Startup | Andrew Chen & Matt Perault

Matt Perault, and Andrew Chen

How AI Is Rewriting the Power Law of Venture Capital

Jen Kha, David George, and Aram Verdiyan

Who Grades the AI Models? | Ben Horowitz & Rayan Krishnan

Ben Horowitz, Erik Torenberg, Jennifer Li, and Rayan Krishnan

OpenAI Researchers on the Future of Mathematical Reasoning

Lisha Li, Mehtaab Sawhney, and Mark Sellke

Can Open Source Keep AI Power From Concentrating?

Sophia Dew, and Lukasz Kaiser

Your AI Doctor Is Coming | Julie Yoo

Julie Yoo, and Sophia Dew

Aaron Levie on Why Open AI Wins

Theo Jaffee, Sofia Puccini, and Aaron Levie

Fei Fei Li: The Race to Build World Models For AI

Martin Casado, Fei-Fei Li, Justin Johnson, and Ben Mildenhall

The $100B Niches Hiding Inside Payments

Erik Torenberg, Alex Rampell, and Max Levchin

Inside Moderna’s Personalized Cancer Vaccine

Jorge Conde, and Stéphane Bancel

Daniel Litt: The Mathematician's Guide to AI

Lisha Li, and Daniel Litt

Gavin Baker: Why AI Demand Is Outrunning Compute Supply

David George, and Gavin Baker

Why a16z Launched the Machine Age Fund | Jen Kha

Jen Kha, Theo Jaffee, and Sophia Dew

Why 1,200 AI Agents Started Working Together | Ryan Greenblatt

Theo Jaffee, and Ryan Greenblatt

The Infrastructure Behind the Machine Age

Ben Horowitz, Erik Torenberg, Martin Casado, and Raghu Raghuram

Inside Cursor: The Anatomy of a Generational Startup

Martin Casado, Sarah Wang, and Matt Bornstein

The State of AI: Macro, Apps, and Consumer

Anish Acharya, and Jen Kha

The New Economics of AI | Martin Casado & Steven Sinofsky

Erik Torenberg, Martin Casado, and Steven Sinofsky

Why Medical AI Needs a Referee | Protege's Engy Ziedan

Daisy Wolf, Eva Steinman, and Engy Ziedan

Martin Casado on Where the Value Is Going in AI

Martin Casado, Theo Jaffee, and Sophia Dew

Microsoft's Deputy CISO on Securing AI Agents

Joel De La Garza, and Aaron Zollman

How Global Networks Are Reshaping Startup Success

Elena Burger, Angela Strange, and Gabriel Vasquez

How Whatnot Built a Global Marketplace

David George, and Grant LaFontaine

How Do You Defend Against AI That Can Hack?

Joel de la Garza, Nick Warner, and Max Pollard

Stripe’s AI Strategy: Build More, Not Less

David George, and Will Gaybrick

Ben Horowitz and Travis Kalanick on Building Again

Erik Torenberg, Ben Horowitz, and Travis Kalanick

The Two Ways to Sell AI: Lighthouse or Landgrab?

Elena Burger, Joe Schmidt, and Andy McCall

Garry Tan on Taste, Agents and Founder Ambition

Anish Acharya, and Garry Tan

The CISO Playbook for AI Agents | Datadog

Joel de la Garza, and Emilio Escobar

The Self-Improving Company | Kavak's AI Playbook

Gabriel Vasquez, Angela Strange, and Alejandro Maza Ayala

The Reality of AI-Powered Cyberattacks | Truffle Security & Socket

Joel De La Garza, Feross Aboukhadijeh, and Dylan Ayrey

The Engine Powering Open-Source AI

Elena Burger, Matt Bornstein, and Simon Mo

Three Startups Reinventing Critical Infrastructure

Erin Price-Wright, Ryan McEntush, Theo Jaffee, Doug Bernauer, Turner Caldwell, Will O'Brien, and Erik Torenberg

OpenAI's Joshua Achiam: Did We Already Reach AGI?

Theo Jaffee, and Joshua Achiam

Ruby Thelot on Internet Culture, AI, and the Future of Taste

Sophia Dew, Sofia Puccini, and Ruby Thelot

Marc Andreessen and Chris Dixon: What’s at Stake in Crypto Regulation

Robert Hackett, Marc Andreessen, and Chris Dixon

How Enterprise AI Really Gets Deployed

Sarah Wang, Kimberly Tan, Jesse Zhang, and Ashwin Sreenivas

AI for America's Small Businesses | Lassie

Olivia Moore, Alex Rampell, Steijn Pelle, and Frédéric Renken

AI Micro Dramas, Generative Media, and the Future of Creativity

Justine Moore

Fei-Fei Li on Spatial Intelligence and Robotics

Martin Casado, Fei-Fei Li, and Yunzhu Li

Steven Sinofsky: AI Doesn't Need New Rules Yet

Steven Sinofsky, Theo Jaffee, and Sofia Puccini

Ben Horowitz: The Fight Over Open Source AI

Ben Horowitz, Theo Jaffee, and Sofia Puccini

Sriram Krishnan on Open Source AI's Biggest Week Yet

Theo Jaffee, Sofia Puccini, and Sriram Krishnan

Building the Physical AI Stack | Travis Kalanick on TBPN

Travis Kalanick, Jordi Hays, and John Coogan

Travis Kalanick Is Back | Building the Future of Industrial AI

Erik Torenberg, Ben Horowitz, and Travis Kalanick

Why Physical AI Is the Next Frontier | Applied Intuition

Erik Torenberg, Marc Andreessen, Qasar Younis, and Peter Ludwig

Hugging Face's CEO on Open Source AI, Model Routing, and the Future of Competition

Theo Jaffee, Sofia Puccini, and Clément Delangue

Amjad Masad on Going Direct, Building Replit, and the Future of Software

Erik Torenberg, and Amjad Masad

More Podcasts From Us

Bio Eats World

From the latest scientific advances to the biggest trends, this show explores all the ways biology is today where the computing revolution was 50 years ago.

16 Minutes on the News

A short news podcast where we cover the top headlines of the week, the a16z podcast way—why these topics are in the news; what’s real and what’s hype.