Featured Episodes

Textiles as Tech, Science, Math, Culture, or Civilization

Virginia Postrel and Sonal Chokshi

AI, WebRTC, Crypto, and Full Stack Startups

Elad Gil, Sep Kamvar, Chris Dixon, and a16zftr

Feedback Loops — Company Culture, Change, and DevOps

Nicole Forsgren, Jez Humble, and Sonal Chokshi

Latest Episodes

What It Takes to Win as a Founder | Ben Horowitz

Ben Horowitz, and Andrew Chen

Amazon CEO Andy Jassy on the $220 Billion AI Buildout

Erik Torenberg, Ben Horowitz, and Andy Jassy

The Frontier Ideas a16z Wants to Fund | Marc Andreessen, Ben Horowitz & Chris Dixon

Chris Dixon, Ben Horowitz, Marc Andreessen, and Erik Torenberg

The Missing Infrastructure for AI Agents: Documents | Reducto’s Adit Abraham

Jennifer Li, and Adit Abraham

What Happens When Everyone Has a Health Expert in Their Pocket? | OpenAI’s Karan Singhal

Jay Rughani, and Karan Singhal

What Happens When Al Agents Can Spend Your Money?

Alex Rampell, and Jean-Denis Greze

Why Real-World AI Is Harder Than the Benchmark | EliseAI’s Mario Martone

Mario Martone, and Sophia Dew

Why AI Could Finally Fix Healthcare Access | Zocdoc CEO Oliver Kharraz

Julie Yoo, and Oliver Kharraz

AI Can Write the Code. Can It Run the System? | Grepr CEO Jad Naous

Martin Casado, and Jad Naous

When AI Agents Start Spending Your Money | Alex Rampell & Terry Angelos

Alex Rampell, and Terry Angelos

Can Open Models Keep Up With the AI Frontier? | Nathan Lambert

Lisha Li, and Nathan Lambert

Can AI Break Cryptography? What the Experts Actually Think

Liz Harkavy, Eddy Lazzarin, Justin Thaler, and Dan Boneh

The Race to Recursive Self-Improving AI

Martin Casado, Dhaval Adjodah, and Owen He

Nick Bostrom: How Should We Navigate Superintelligence?

Theo Jaffee, Sofia Puccini, and Nick Bostrom

What Makes a Great Entrepreneur? | Ben Horowitz on Vintage x Vintage

Ben Horowitz, and James Norman

Chips, Memory, and Power | Pat Gelsinger

Raghu Raghuram, Guido Appenzeller, and Pat Gelsinger

Building the Cloud for an Agentic World | AWS CEO Matt Garman

Raghu Raghuram, and Matt Garman

How Valon Rebuilt a $13 Trillion Industry From Scratch

Angela Strange, Linda Du, and Andrew Wang

Building Defense for the Agentic Era: Kevin Mandia

David George, and Kevin Mandia

The Top 100 Consumer AI Apps: Who’s Actually Paying?

Elena Burger, Olivia Moore, and Josh Elman

David George & Jack Altman on AI, Autonomy, and the Next $25 Trillion

David George, and Jack Altman

Beyond the God Model | Alex Atallah & Amjad Masad

Erik Torenberg, Amjad Masad, and Alex Atallah

Why AI Agents Can Beat the Incumbents

Elena Burger, Seema Amble, and Vladimir Keil

Rebuilding the Internet for Privacy | Barrett Lyon on DoxxNet

Joel de la Garza, and Barrett Lyon

The $1 Trillion AI Buildout | State of Markets

David George, Sarah Wang, Alex Immerman, and Santiago Rodriguez

The Personal Agent Race Is Here | Anish Acharya & David Pawlan

Anish Acharya, and David Pawlan

AI Can Write Code. Why Isn’t Software Better?

Ben Horowitz, Martin Casado, and Diogo Almeida

Building a Team at AI Speed | Harvey’s Maggie Landers

Katie Kirsch, and Maggie Landers

Aaron Levie, Steven Sinofsky & Martin Casado: How Do You Secure a World of AI Agents?

Erik Torenberg, Martin Casado, Steven Sinofsky, and Aaron Levie

The Reputation Graph of Silicon Valley | Introducing Cosign

Erik Torenberg, Josh Elman, Olivia Moore, and David Booth

The Case Against an AI Pause | Eddy Lazzarin

Theo Jaffee, and Eddy Lazzarin

Amjad Masad on Rethinking College for the AI Era

Erik Torenberg, Amjad Masad, and Gagan Biyani

Why a16z is Building a New School for the AI Era | Ben Horowitz

Ben Horowitz, Gagan Biyani, and Erik Torenberg

AI Safety Language Is Destroying the Debate | Steven Sinofsky

Steven Sinofsky, Theo Jaffee, and Sofia Puccini

Nas, Grandmaster Caz, Steve Stoute & Ben Horowitz on Paying Hip-Hop’s Pioneers Their Due

Ben Horowitz, Erik Torenberg, Nas, Steve Stoute, and Grandmaster Caz

What Makes a Consumer AI Product Stick? | Josh Elman

Josh Elman, and Ollie Forsyth

Databricks CEO on AI Pacing, Cyber Risk, and the Enterprise

Sarah Wang, Martin Casado, and Ali Ghodsi

The Next Frontier of AI Video Is Control

Jennifer Li, Gorkem Yurtseven, and Batuhan Taskaya

The AI-Native CRM

Joe Schmidt, Alex Rampell, and Keith Peiris

The Age of Body Futurism | Ruby Justice Thelot

Elena Burger, and Ruby Justice Thelot

Greg Brockman on Why OpenAI Says We’re Entering the AGI Era

Ben Horowitz, Erik Torenberg, and Greg Brockman

World Models, Robotics, and the Future of 3D AI

Theo Jaffee, Sofia Puccini, and Justin Johnson

Why Companies Are Becoming a Series of Loops | Anish Acharya on Lenny’s Podcast

Anish Acharya, and Lenny Rachitsky

What It Takes to Build a Startup | Andrew Chen & Matt Perault

Matt Perault, and Andrew Chen

How AI Is Rewriting the Power Law of Venture Capital

Jen Kha, David George, and Aram Verdiyan

Who Grades the AI Models? | Ben Horowitz & Rayan Krishnan

Ben Horowitz, Erik Torenberg, Jennifer Li, and Rayan Krishnan

OpenAI Researchers on the Future of Mathematical Reasoning

Lisha Li, Mehtaab Sawhney, and Mark Sellke

Can Open Source Keep AI Power From Concentrating?

Sophia Dew, and Lukasz Kaiser

Your AI Doctor Is Coming | Julie Yoo

Julie Yoo, and Sophia Dew

Aaron Levie on Why Open AI Wins

Theo Jaffee, Sofia Puccini, and Aaron Levie

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Bio Eats World

From the latest scientific advances to the biggest trends, this show explores all the ways biology is today where the computing revolution was 50 years ago.

16 Minutes on the News

A short news podcast where we cover the top headlines of the week, the a16z podcast way—why these topics are in the news; what’s real and what’s hype.